How does high sensitivity stack up against the OCEAN model? The biggest correlations, in my view, are openness to new experiences and conscientiousness. Of course, we know that 30% of HSPs are also extraverts and that neuroticism and agreeableness do not necessarily follow from being highly sensitive. HSPs CAN be neurotic and CAN be agreeable but, in and of itself, sensitivity is neutral and does not imply anything beyond a greater openness to all stimulation and a more thorough processing of those events, experiences, memories, etc.
As mentioned in the link, many other factors shape and form how we develop as human beings with sensory processing sensitivity representing a strong, heritable trait present in the human population in a large minority 15-20%. The trick really is utilizing it in the world for its many insights, its creativity, and its ability to connect us together through vulnerability and empathy.